The surplus fluid in the interstitial space that is not returned directly back to the capillaries is drained from tissues by the lymphatic system, and then re-enters the vascular system at the subclavian veins. Filtration pressure squeezes fluid from the plasma in the blood to the IF surrounding the tissue cells. Fluid and the cellular wastes in the tissues enter the capillaries at the venule end, where the hydrostatic pressure is less than the osmotic pressure in the vessel. This pressure forces plasma and nutrients out of the capillaries and into surrounding tissues. In capillaries, hydrostatic pressure (also known as capillary blood pressure) is higher than the opposing “colloid osmotic pressure” in blood-a “constant” pressure primarily produced by circulating albumin-at the arteriolar end of the capillary. The hydrostatic pressure of blood is the pressure exerted by blood against the walls of the blood vessels by the pumping action of the heart. Hydrostatic pressure, the force exerted by a fluid against a wall, causes movement of fluid between compartments. (credit: modification of work by Mariana Ruiz Villarreal) The pump also transfers potassium out of the ECF and into the cytoplasm. The sodium-potassium pump is powered by ATP to transfer sodium out of the cytoplasm and into the ECF. These pumps use the energy supplied by ATP to pump sodium out of the cell and potassium into the cell. Although sodium and potassium can “leak” through “pores” into and out of cells, respectively, the high levels of potassium and low levels of sodium in the ICF are maintained by sodium-potassium pumps in the cell membranes. As seen in the previous graph, sodium (Na ) ions and chloride (Cl –) ions are concentrated in the ECF of the body, whereas potassium (K ) ions are concentrated inside cells. Thus, cations, or positively charged ions, and anions, or negatively charged ions, are balanced in fluids. When blood volume decreases due to sweating, from what source is water taken in by the blood? Watch this video to learn more about body fluids, fluid compartments, and electrolytes. Because these fluids are outside of cells, these fluids are also considered components of the ECF compartment. These include the cerebrospinal fluid that bathes the brain and spinal cord, lymph, the synovial fluid in joints, the pleural fluid in the pleural cavities, the pericardial fluid in the cardiac sac, the peritoneal fluid in the peritoneal cavity, and the aqueous humor of the eye. Cells are separated from the IF by a selectively permeable cell membrane that helps regulate the passage of materials between the IF and the interior of the cell. Gases, nutrients, and waste materials travel between capillaries and cells through the IF. Plasma travels through the body in blood vessels and transports a range of materials, including blood cells, proteins (including clotting factors and antibodies), electrolytes, nutrients, gases, and wastes. Approximately 20 percent of the ECF is found in plasma. The ECF accounts for the other one-third of the body’s water content. An appropriate balance of solutes inside and outside of cells must be maintained to ensure normal function. As a result, water will move into and out of cells and tissues, depending on the relative concentrations of the water and solutes found there. Osmosis is basically the diffusion of water from regions of higher concentration to regions of lower concentration, along an osmotic gradient across a semi-permeable membrane. In the body, water moves through semi-permeable membranes of cells and from one compartment of the body to another by a process called osmosis. For instance, sodium ions (Na ) and chloride ions (Cl –) are often referred to as electrolytes. Often in medicine, a mineral dissociated from a salt that carries an electrical charge (an ion) is called and electrolyte. In the human body, solutes vary in different parts of the body, but may include proteins-including those that transport lipids, carbohydrates, and, very importantly, electrolytes. The dissolved substances in a solution are called solutes. The chemical reactions of life take place in aqueous solutions.
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